Lyme Disease
In most people, the first evidence of Lyme disease infection consists of a “bulls eye” skin rash at the site of the tick bite or developing such flu-like symptoms as fatigue, fever, headache, stiff neck, and/or muscle or joint pain within three to 30 days after being bitten by an infected tick.

The “bulls eye” rash, called erythema migrans (EM), is red and slowly gets bigger, usually with a clearing in the center. It is not painful and does not itch.

Possible Complications
Both the rash and flu-like symptoms may last up to several weeks and will typically go away with or without treatment. If the early infection is not treated though, other problems may develop such as nervous system disorders, heart problems, or joint swelling and pain.